VINCENT VACATIONS
21-NIGHT CRUISE SPECIALS | SOUTH AMERICA

21-Night South America Cruises & Sailing Dates

Compare 16 upcoming sailings and 4 unique itineraries for 21-night voyages to South America starting from $4,231 per person.

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All Cruises Hub 34 Cruise Lines 450+ Cruise Ships 76 Destinations 293 Departure Ports Top Deals & Onboard Credit
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LEADING FLEETS

Top Cruise Lines in South America

MSC Cruises (495 sailings)AmaWaterways (359 sailings)Globus (205 sailings)Seabourn (112 sailings)Avalon Waterways (80 sailings)Cosmos (66 sailings)Uniworld Boutique River Cruises (40 sailings)Viking Expeditions (29 sailings)Celebrity Cruises (25 sailings)Silversea (24 sailings)Scenic Luxury Cruises & Tours (23 sailings)Holland America (20 sailings)
EMBARKATION CITIES

Top Departure Ports for South America

Lima (276 departures)Buenos Aires (230 departures)Santos (167 departures)Rio De Janeiro (129 departures)Cartagena (125 departures)Medellin (124 departures)Barranquilla (111 departures)Quito (55 departures)Salvador (39 departures)Valparaiso (39 departures)Manaus (36 departures)Balneario Camboriu (29 departures)
PORT-BY-PORT SCHEDULES

21-Night South America Cruise Itineraries (4 Shown)

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21 NightsSeabournSeabourn Venture🎁 Explore Beyond Event - Up to $2,000 Shipboard Credit per Suite!

21-Night Ultimate Antarctica, Falklands - Tour An3

Embark: Buenos Aires → Debark: Ushuaia • Region: South America

Ports of Call: Buenos Aires • Ushuaia • Antarctic Experience • South Georgia Expedition • Port Stanley • Falkland Island Experience

13 Available Departures • Next Sailing: Nov 21, 2026

Nov 21, 2026 ($20,998)Dec 21, 2026 ($22,098)Mar 02, 2027 ($28,197)Nov 18, 2027 ($27,497)
Fares Starting From$20,998Balcony from $20,998 • Suite from $34,997
Dates & Day-by-DayGet Quote & Perks →
THE SIGNATURE TRAVEL NETWORK ADVANTAGE

Why Book 21-Night South America Cruises with Vincent Vacations Instead of Direct?

You pay the exact same promotional cruise line rate with $0 agency booking fees, while unlocking exclusive consortium perks unavailable on retail websites:

✓ $100–$600+ Shipboard Credits✓ Private Car & Driver Shore Excursions✓ Hosted Voyages & VIP Receptions✓ 100% Loyalty Points + Promo Stacking✓ Price-Drop Monitoring Before Final Payment
Request Custom Quote & Perks →Call 1-888-883-0460Already booked direct within 60 days? Ask about our complimentary perk transfer.
EXPERT CRUISE GUIDANCE

Frequently Asked Questions About 21-Night South America Cruises

How much does a 21-night South America cruise cost?

We currently track 16 21-night South America sailings across 4 itineraries, with stateroom fares starting from $4,231 per person before taxes and port fees.

How do I get extra onboard credit on a 21-night South America cruise?

Request a custom quote on this page or call 1-888-883-0460. Our certified cruise advisors match all promotional fares and attach exclusive Signature Travel Network perks ($100-$600+ shipboard credit) on eligible 21-night South America voyages.

Which cruise lines offer 21-night South America voyages?

Browse the complete fleet of 21-night itineraries below to compare lines, ships, and departure dates sailing South America.

Signature Travel Network Perks: Up to $600 Shipboard Credit + Price-Match Guarantee + $0 Booking Fees
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